This study examines the operational strategies employed by Nigeria’s anti-graft agency, the Economic and Financial Crimes Commission (EFCC), to fight corruption under President Muhammadu Buhari’s administration from 2015 to 2023. The study is theoretically anchored on Social Disorganisation Theory. Drawing on a mixed-method survey design, structured questionnaires were distributed to 384 respondents drawn from the Commission, with 376 valid responses retrieved, representing a 97.7% response rate. In-depth semi-structured interviews were also conducted with key institutional stakeholders including agency officers, Federal High Court judges, civil society representatives, and Federal civil servants. Quantitative data were analysed using frequency distribution tables, percentages, while thematic analysis method was used for qualitative data. The findings reveal that investigation and surveillance emerged as the most effective operational strategies employed by the EFCC, followed closely by inter-agency collaboration and international cooperation. In contrast, prosecution, legal frameworks, and plea bargaining were rated as the least effective strategies, primarily due to political interference, judicial delays, and legislative gaps. The study concludes that while the EFCC made notable use of intelligence-led investigative strategies, its overall operational impact was constrained by political interference, weak legal frameworks, and poor institutional coordination. The study recommends for legislative reforms to guarantee agency autonomy, judicial reforms to accelerate corruption case resolution, and investment in digital anti-corruption technologies.