This study investigated the effects of laboratory pedagogies on interest in Biology among varied ability secondary school students in Taraba State, Nigeria. The study adopted a quasi-experimental research design, and data was collected using the Students’ Interest in Biology Scale (SIBS) instrument. The study formulated 18 research questions and 18 research hypotheses. The population of the study is 816 out of which a sample of 187 was drawn using multi-stage random sampling technique. A pilot study was used to test for the reliability of the research instrument. The results show that students' interest in Biology varied depending on the teaching method used. Indoor laboratory pedagogy showed a significant effect on students’

interest in Biology (P=0.013