The study assessed the use of radio in promoting the use of Insecticide Treated Nets (ITNs) in Makurdi Metropolis. Among other things, the paper sought to identify specific radio programme(s) that promote the use of Insecticide Treated Nets in Makurdi Metropolis, as well as find out the ways by which those radio programmes promote the use of ITNs. The paper was anchored on the Agenda Setting Theory. The research design adopted for the study was survey research method using questionnaire as the research instruments for data collection. Findings from the study revealed that the use of radio as a tool in promoting the use of ITNs in Makurdi metropolis taught listeners how to accept modern malaria prevention methods. Programmes such as Mama Bon Boy on Harvest FM, Health Watch on Brothers FM and You and Your Health on Radio Benue have promoted the use of ITNs. The study concluded that even though, there are challenges associated with the promotion of the use of radio as a tool in promoting ITNs such as language barrier, the study recommended that these programmes should be produced in local dialect so that they can be understood by all especially those who cannot understand English language.