This paper investigates the impact of cultural and social stigma on self-adjustment of persons with visual impairment in Nigeria. The purpose of this study is to examine the joint contributions of cultural and social stigma to self-adjustment of persons with visual impairment and investigates the relative contribution of cultural and social stigma to self-adjustment of persons with visual impairment. The study adopted a descriptive survey research design, while purposive sampling technique was used to select Seventy respondent for the study, who were persons with visual impairment including male (38) and female (32) with total blindness as well as low vision. A questionnaire method was used to collect the data for the study and it was divided into four parts.

Pearson Product Moment Correlation (PPMC) and Multiple Regression Analysis (MRA) were used in analysing data collected from the field. The findings revealed that there is a significant relationship between self-adjustment of persons with visual impairment and cultural stigma (r=0.306, p< 0.05) and social stigma (r=0.334, p<0.05) thejoint effect of cultural and social stigma on self-adjustment yields a coefficient of multiple regressions R = .345; R2 = .219 and adjusted R-square = 0.193. This suggests that these two factors jointly account for 19.3% (Adj.R2= .193) variance in the prediction of Self adjustment. The study recommends that family, school, different cultural groups and the communityshould accept persons with visual impairment through caring and supportive attitude M, also, learn to accommodate them.