Post-harvest losses of sweet potatoes pose a major challenge to food security, income generation, and agricultural sustainability, particularly among smallholder farmers in developing regions. This study investigates the extent of post-harvest losses among adopters and non-adopters of value-added innovations of sweet potatoes in Vandeikya Local Government Area of Benue State, Nigeria. The objective is to evaluate the extent of post-harvest losses between adopters and non-adopters of value-added innovations of sweet potatoes, the population comprises sweet potatoes farmers, Cochran’s (1977) formula was utilised and a sample size of 384 was determined. A mixed methods design was employed and data were collected using structured interview, focus group discussion and key informant interview. The data obtained were triangulated making use of descriptive analysis, frequencies, means and t-test statistics. The result showed that, a greater number of 349 respondents were non-adopters of modern value-added innovations of sweet potatoes, while only 35 respondents were adopters. The result revealed that adopters of value-added innovations fell most within the smaller extent of post-harvest losses, (0-20%) while non-adopters seemed to maintain a steady rise in post-harvest losses, majority fell within (80-100%) and there was a significant difference in the extent of post-harvest losses between adopters and non-adopters of value-added innovations of the crop. The study concluded that increase in adoption of value-added innovations of sweet potatoes resulted in a decrease in the extent of post-harvest losses. Therefore, the government, could use this result as reference point for advocacy via mass media, for the adoptions of value-added innovations of sweet potatoes. Moreover, philanthropist, Non-Governmental Organisations and the government should provide cottage industries and logistics to farmers for enhancing adoption of value-added innovations and control postharvest losses of sweet potatoes in the study area and Nigeria at large.